We are a patient-driven nonprofit dedicated to researching better therapies and a cure for angiosarcoma.

Current Research Project

Dr. Antonescu has drafted a budget based on a large scale genomic analysis of angiosarcoma tumors. Her current work has revealed that certain genes are upregulated in angiosarcomas even though there are no genetic mutations associated with the DNA that encodes those genes. The genes of interest are described in the manuscript linked below, many of which are involved in what would be considered “normal” angiogenesis. The fact that she has found them to be differentially regulated in angiosarcoma tumors has led to the hypothesis that there are epigenetic regulators of these genes that have yet to be identified through the genomic profiling applied to these studies thus far.